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Low copy target detection by droplet digital PCR through application of a novel open access bioinformatic pipeline, ‘definetherain’

Abstract:

Droplet Digital PCR (ddPCR) represents a new and alternative platform to conventional quantitative-PCR (qPCR) for the quantitation of DNA templates. However, the proposed improvement in sensitivity and reproducibility offered by ddPCR is not yet fully proven, partly because the delineation between positive and negative responses is not always clear. Data are presented demonstrating the sensitivity of the ddPCR system to both reagent concentrations and choice of cut-off for defining positive a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jviromet.2014.02.020

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
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Institution:
University of Oxford
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Publisher:
Elsevier B.V.
Journal:
J Virol Methods Journal website
Volume:
202
Issue:
2014
Pages:
46-53
Publication date:
2014-01-01
DOI:
EISSN:
1879-0984
ISSN:
0166-0934
URN:
uuid:92d28c1a-b887-4377-8d38-c718aa8bdbf3
Source identifiers:
447618
Local pid:
pubs:447618

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