Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Journal article

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide an...

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Authors: Perry, JR; Day, F; Elks, C; Sulem, P; Thompson, D

• Publication status: Published
• Journal: Nature
• Volume: 514
• Issue: 7520
• Pages: 92-97
• Publication date: 2014-10-01
• DOI: 10.1038/nature13545
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: GENICA Network; Age Factors; Potassium Channels, Tandem Pore Domain; Genomic Imprinting; Europe; Ovary; Genetic Loci; Parents; Obesity; Alleles; Male; Receptors, GABA-B; Adolescent; Receptors, Retinoic Acid; Menarche; Quantitative Trait Loci; InterAct Consortium; Proteins; Early Growth Genetics (EGG) Consortium; Genome-Wide Association Study; Membrane Proteins; Humans; Ribonucleoproteins; Cardiovascular Diseases; Hypothalamo-Hypophyseal System; Female; Child; Australian Ovarian Cancer Study; Breast Neoplasms; Diabetes Mellitus, Type 2; Body Mass Index; LifeLines Cohort Study; kConFab; Intercellular Signaling Peptides and Proteins; Polymorphism, Single Nucleotide