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Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

Abstract:

Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes, glucagon secretion is not suppressed at high glucose, exacerbating the consequences of insufficient insulin secretion, and is inadequate at low glucose, potentially leading to fatal hypoglycemia. The causal mechanisms remain unknown. Here we show that α cell KATP-channel activity is very low under hypoglycemic conditions and that hyperglycemia, via elevated intracellular ATP/ADP, leads to comp...

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Publication status:
Published

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Publisher copy:
10.1016/j.cmet.2013.10.014

Authors


Ramracheya, R More by this author
Lahmann, C More by this author
Tarasov, A More by this author
Bengtsson, M More by this author
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Journal:
Cell metabolism
Volume:
18
Issue:
6
Pages:
871-882
Publication date:
2013-12-05
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
URN:
uuid:92cbe320-691d-4128-aada-be3e03426802
Source identifiers:
441672
Local pid:
pubs:441672

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