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The influence of toxicity constraints in models of chemotherapeutic protocol escalation.

Abstract:

The prospect of exploiting mathematical and computational models to gain insight into the influence of scheduling on cancer chemotherapeutic effectiveness is increasingly being considered. However, the question of whether such models are robust to the inclusion of additional tumour biology is relatively unexplored. In this paper, we consider a common strategy for improving protocol scheduling that has foundations in mathematical modelling, namely the concept of dose densification, whereby res...

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Publisher copy:
10.1093/imammb/dqr004

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Mathematical medicine and biology : a journal of the IMA
Volume:
28
Issue:
4
Pages:
357-384
Publication date:
2011-12-05
DOI:
EISSN:
1477-8602
ISSN:
1477-8599
URN:
uuid:92c93d14-8a23-40a7-b02f-0b380e8a8c44
Source identifiers:
130835
Local pid:
pubs:130835

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