- Abstract:
-
In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, the most distinct of all the myelodysplastic syndromes. It is now recognized that p53 activation, caused by haploinsufficiency for the ribosomal gene RPS14 (mapping to the commonly deleted region), is the probable cause of the erythroid defect in the 5q- syndrome. A mouse model of the human 5q- syndrome has been generated by large-scale deletion of the Cd74-Nid67 interval (containing Rps14) and t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.2174/1381612811209023180
-
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- Journal:
- Current pharmaceutical design
- Volume:
- 18
- Issue:
- 22
- Pages:
- 3180-3183
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1873-4286
- ISSN:
-
1381-6128
- URN:
-
uuid:92bccc99-6cfa-48a8-b591-1190287447a6
- Source identifiers:
-
329109
- Local pid:
- pubs:329109
- Copyright date:
- 2012
Journal article
5q- syndrome.
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