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The novel monoamine reuptake inhibitor and potential antidepressant, S33005, induces Arc gene expression in cerebral cortex.

Abstract:

Recent data show that corticolimbic expression of the effector immediate early gene Arc is up-regulated by standard antidepressant drugs. Here, we tested the effect upon Arc expression of a novel antidepressant and selective 5-hydroxytryptamine/noradrenaline reuptake inhibitor (SNRI), (-)1-(1-dimethylaminomethyl) 5-methoxybenzocyclobutan-1-yl) cyclohexanol (S33005). Arc mRNA abundance in frontal, cingulate, orbital and parietal cortices, hippocampus (CA1 pyramidal layer) and striatum was elev...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
European journal of pharmacology
Volume:
495
Issue:
2-3
Pages:
227-233
Publication date:
2004-07-05
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
URN:
uuid:92b5b8b2-a7f9-4167-835c-d6dca612dae7
Source identifiers:
185343
Local pid:
pubs:185343

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