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Targeting group II PAKs in cancer and metastasis.

Abstract:

The p21 activated kinases (PAKs) play an essential role in cell signaling and control a variety of cellular functions including cell motility, survival, angiogenesis and mitosis. PAKs are important regulators in growth factor signaling, cytoskeletal reorganization and growth factor-mediated cell migration. Overexpression of PAKs has been detected in many cancers and linked to increased migration potential, anchorage independent growth and metastasis. Six isoforms of PAKs are expressed in huma...

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Publication status:
Published

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Publisher copy:
10.1007/s10555-008-9181-4

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Cancer metastasis reviews
Volume:
28
Issue:
1-2
Pages:
209-217
Publication date:
2009-06-01
DOI:
EISSN:
1573-7233
ISSN:
0167-7659
Source identifiers:
34567

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