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Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach

Abstract:

Artemisinin-resistant falciparum malaria has emerged in Southeast Asia, posing a major threat to malaria control. It is characterised by delayed asexual-stage parasite clearance, which is the reference comparator for the molecular marker 'Kelch 13' and in vitro sensitivity tests. However, current cut-off values denoting slow clearance based on the proportion of individuals remaining parasitaemic on the third day of treatment ('day-3'), or on peripheral blood parasite half-life, are not well s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1001823

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Department:
Wadham College
Role:
Author
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Institution:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Wellcome Trust More from this funder
Howard Hughes Medical Institute More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
12
Issue:
4
Pages:
e1001823
Publication date:
2015-04-28
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Pubs id:
pubs:521308
URN:
uri:92a059d1-a399-4e69-978e-1a4f924cbf5f
UUID:
uuid:92a059d1-a399-4e69-978e-1a4f924cbf5f
Local pid:
pubs:521308
Paper number:
4

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