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Journal article

Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.

Abstract:

LMO2 is a transcription regulator involved in human T-cell leukemia, including some occurring in X-SCID gene therapy trials, and in B-cell lymphomas and prostate cancer. LMO2 functions in transcription complexes via protein-protein interactions involving two LIM domains and causes a preleukemic T-cell development blockade followed by clonal tumors. Therefore, LMO2 is necessary but not sufficient for overt neoplasias, which must undergo additional mutations before frank malignancy. An open que...

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Journal:
Cancer research
Volume:
69
Issue:
11
Pages:
4784-4790
Publication date:
2009-06-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:929c42fd-f3e5-4a1d-bdac-e74bc8cd933b
Source identifiers:
324256
Local pid:
pubs:324256

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