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Journal article

Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults.

Abstract:

Respiratory syncytial virus (RSV) causes respiratory infection in annual epidemics, with infants and the elderly at particular risk of developing severe disease and death. However, despite its importance, no vaccine exists. The chimpanzee adenovirus, PanAd3-RSV, and modified vaccinia virus Ankara, MVA-RSV, are replication-defective viral vectors encoding the RSV fusion (F), nucleocapsid (N), and matrix (M2-1) proteins for the induction of humoral and cellular responses. We performed an open-l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1126/scitranslmed.aac5745

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Scarselli, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine
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ReiThera SRL More from this funder
NIHR Oxford Biomedical Research More from this funder
Wellcome Trust More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science translational medicine Journal website
Volume:
7
Issue:
300
Pages:
300ra126
Publication date:
2015-08-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
URN:
uuid:9299f417-4ee8-42be-b5f6-3e30decc9266
Source identifiers:
539407
Local pid:
pubs:539407
Language:
English

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