Journal article
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors
- Abstract:
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Understanding how cellular decisions by receptor/ligand interactions at cell/cell interface has been challenging because it is difficult to independently vary the surface density of multiple ligands. Here, we exploit the SpyCatcher/SpyTag split-protein system for rapid combinatorial display of native ligands on cells (Combicells). We use this platform to assess T cell antigen sensitivity and the impact of T cell co-stimulation/co-inhibition receptors. The TCR displayed much greater sensitivit...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 2.4MB, Terms of use)
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- Publisher copy:
- 10.1038/s44318-023-00012-1
Authors
Funding
Bibliographic Details
- Publisher:
- EMBO Press
- Journal:
- EMBO journal More from this journal
- Volume:
- 43
- Issue:
- 1
- Pages:
- 132 - 150
- Publication date:
- 2023-12-18
- Acceptance date:
- 2023-11-10
- DOI:
- EISSN:
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1460-2075
- ISSN:
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0261-4189
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1582049
- Local pid:
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pubs:1582049
- Deposit date:
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2023-12-13
Terms of use
- Copyright holder:
- Patel et al
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Author(s). Open Access.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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