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Journal article

Native structure of a retroviral envelope protein and its conformational change upon interaction with the target cell.

Abstract:

Enveloped viruses enter their host cells by membrane fusion. The process of attachment and fusion in retroviruses is mediated by a single viral envelope glycoprotein (Env). Conformational changes of Env in the course of fusion are a focus of intense studies. Here we provide further insight into the changes occurring in retroviral Env during its initial interaction with the cell, employing murine leukemia virus (MLV) as model system. We first determined the structure of both natively membrane ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.jsb.2016.06.017

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Lehmann, MJ More by this author
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Funding agency for:
Grünewald, K
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Funding agency for:
Grünewald, K
German National Academy of Science More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Structural Biology Journal website
Publication date:
2016-06-05
DOI:
EISSN:
1095-8657
ISSN:
1047-8477
URN:
uuid:92768995-4789-4b6c-ba17-4da43c4a6597
Source identifiers:
630927
Local pid:
pubs:630927

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