Journal article icon

Journal article

Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.

Abstract:

Integrins are large membrane-spanning receptors fundamental to cell adhesion and migration. Integrin adhesiveness for the extracellular matrix is activated by the cytoskeletal protein talin via direct binding of its phosphotyrosine-binding-like F3 domain to the cytoplasmic tail of the beta integrin subunit. The phosphotyrosine-binding domain of the signaling protein Dok1, on the other hand, has an inactivating effect on integrins, a phenomenon that is modulated by integrin tyrosine phosphoryl...

Expand abstract

Actions


Access Document


Publisher copy:
10.1074/jbc.m109.061275

Authors


Expand authors...
Journal:
The Journal of biological chemistry
Volume:
284
Issue:
52
Pages:
36700-36710
Publication date:
2009-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:925f061f-915e-448b-a269-c2a4097deef1
Source identifiers:
246552
Local pid:
pubs:246552

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP