Journal article
Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.
- Abstract:
-
Integrins are large membrane-spanning receptors fundamental to cell adhesion and migration. Integrin adhesiveness for the extracellular matrix is activated by the cytoskeletal protein talin via direct binding of its phosphotyrosine-binding-like F3 domain to the cytoplasmic tail of the beta integrin subunit. The phosphotyrosine-binding domain of the signaling protein Dok1, on the other hand, has an inactivating effect on integrins, a phenomenon that is modulated by integrin tyrosine phosphoryl...
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- Publisher copy:
- 10.1074/jbc.m109.061275
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 284
- Issue:
- 52
- Pages:
- 36700-36710
- Publication date:
- 2009-12-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
246552
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:246552
- UUID:
-
uuid:925f061f-915e-448b-a269-c2a4097deef1
- Local pid:
- pubs:246552
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2009
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