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Journal article

Exploring the unknown: assumptions about allelic architecture and strategies for susceptibility variant discovery.

Abstract:

Identification of common-variant associations for many common disorders has been highly effective, but the loci detected so far typically explain only a small proportion of the genetic predisposition to disease. Extending explained genetic variance is one of the major near-term goals of human genetic research. Next-generation sequencing technologies offer great promise, but optimal strategies for their deployment remain uncertain, not least because we lack a clear view of the characteristics ...

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Publication status:
Published

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Publisher copy:
10.1186/gm66

Authors


McCarthy, MI More by this author
Journal:
Genome medicine
Volume:
1
Issue:
7
Pages:
66
Publication date:
2009
DOI:
EISSN:
1756-994X
ISSN:
1756-994X
URN:
uuid:925ad5f4-be22-4ad8-be24-5ccea9685146
Source identifiers:
1329
Local pid:
pubs:1329
Language:
English

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