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Journal article

VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment.

Abstract:

Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C and -D on VEGFR3. In contrast, VEGF-A binds VEGFR1 and VEGFR2 and is an essential hemangiogenic factor. We re-evaluated the potential role of VEGF-A in lymphangiogenesis using a novel model in which both lymphangiogenesis and hemangiogenesis are induced in the normally avascular cornea. Administration of VEGF Trap, a receptor-based fusion protein that binds and ne...

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Publication status:
Published

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Publisher copy:
10.1172/jci20465

Authors


Cursiefen, C More by this author
Borges, LP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
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Journal:
The Journal of clinical investigation
Volume:
113
Issue:
7
Pages:
1040-1050
Publication date:
2004-04-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:924ddbc6-34e1-4239-9ebd-6596b8eb4c01
Source identifiers:
102436
Local pid:
pubs:102436

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