High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals.

Journal article

Human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) have been detected in most patients following infection. It has also been suggested that the specific CTL response, which may play an important role in delaying disease in infected humans, may decline during the course of disease progression. We have measured HIV peptide specific CTL precursor frequency by limiting dilution analysis in two healthy seropositive patients whose fresh peripheral blood mononuclear c...

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Authors: Gotch, F; Nixon, D; Alp, N; Mcmichael, A; Borysiewicz, L

• Publication status: Published
• Journal: International immunology
• Volume: 2
• Issue: 8
• Pages: 707-712
• Publication date: 1990-01-01
• DOI: 10.1093/intimm/2.8.707
• EISSN: 1460-2377
• ISSN: 0953-8178
• Language: English
• Keywords: Gene Products, gag; T-Lymphocytes, Cytotoxic; HIV Seropositivity; Immunologic Memory; Humans; Hematopoietic Stem Cells; Cytotoxicity, Immunologic; HIV-1