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Acute increases in serum creatinine after starting angiotensin-converting enzyme inhibitor-based therapy and effects of its continuation on major clinical outcomes in type 2 diabetes mellitus: the ADVANCE trial

Abstract:

Discontinuation of angiotensin-converting enzyme (ACE) inhibitor is recommended if patients experience ≥30% acute increase in serum creatinine after starting this therapy. However, the long-term effects of its continuation or discontinuation on major clinical outcomes after increases in serum creatinine are unclear. In the ADVANCE trial (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation), 11 140 diabetes mellitus patients were randomly assi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1161/HYPERTENSIONAHA.118.12060

Authors


Rodgers, A More by this author
Glasziou, P More by this author
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Funding agency for:
Ohkuma, T
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Funding agency for:
Jun, M
National Health and Medical Research Council of Australia More from this funder
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Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
73
Issue:
1
Pages:
84-91
Publication date:
2018-11-27
Acceptance date:
2018-10-25
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Pubs id:
pubs:935227
URN:
uri:92368217-252c-41eb-8433-fc85765ca4b3
UUID:
uuid:92368217-252c-41eb-8433-fc85765ca4b3
Local pid:
pubs:935227

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