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Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints.

Abstract:

We previously proposed the hypothesis that the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA) based on our observations that it is the dominant inducer of interleukin-1 (IL-1) and granulocyte-macrophage colony-stimulating factor (GM-CSF) production in RA synovial joint mononuclear (MNC) cells in culture. Since TNF-alpha acts via two membrane receptors, we have extended those studies to investigate the dis...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830220734

Authors


Brennan, FM More by this author
Gibbons, DL More by this author
Mitchell, T More by this author
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Journal:
European journal of immunology
Volume:
22
Issue:
7
Pages:
1907-1912
Publication date:
1992-07-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:9232b718-290c-44f2-9935-26e282969f93
Source identifiers:
481722
Local pid:
pubs:481722

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