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Enhancement of adipose-derived stem cell differentiation in scaffolds with IGF-I gene impregnation under dynamic microenvironment.

Abstract:

Biochemical and mechanical signals enabling cardiac regeneration can be elucidated by using in vitro tissue engineering models. We hypothesized that human insulin-like growth factor-I (IGF-I) and 3-dimensional (3D) dynamic microenvironment could enhance the survival and differentiation of adipose tissue-derived stem cells (ADSCs). In this study, ADSCs were cultured on 3D porous scaffolds with or without plasmid DNA PIRES2-IGF-I in cardiac media, in static culture dishes, and in a spinning fla...

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Publication status:
Published

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Publisher copy:
10.1089/scd.2010.0054

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
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Journal:
Stem cells and development
Volume:
19
Issue:
10
Pages:
1547-1556
Publication date:
2010-10-05
DOI:
EISSN:
1557-8534
ISSN:
1547-3287
URN:
uuid:920b82aa-066c-4c60-9700-b6fee5a92005
Source identifiers:
90841
Local pid:
pubs:90841

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