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Transcription and replication of the influenza a virus genome.

Abstract:

The genome of influenza A virus consists of eight segments of negative-strand viral RNA (vRNA). During the replication cycle of the virus, the genomic vRNA is transcribed into positive-strand mRNA and complementary RNA (cRNA) in the cell nucleus. The promoter for the synthesis of mRNA molecules is located in a partially double-stranded RNA structure formed by the 5'- and 3'-terminal sequences of genomic vRNA segments. The virus encoded RNA-dependent RNA polymerase complex has to interact with...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Acta virologica
Volume:
44
Issue:
5
Pages:
273-282
Publication date:
2000-10-05
EISSN:
1336-2305
ISSN:
0001-723X
URN:
uuid:9205c0c3-604c-4c67-8039-a2be729a50d6
Source identifiers:
20143
Local pid:
pubs:20143

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