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Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth.

Abstract:

Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X receptor-alpha (RXRA) is an essential cofactor in the action of 1,25-dihydroxyvitamin D (1,25[OH]2 -vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual-energy X-ray absorptiometry,...

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Publication status:
Published

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Publisher copy:
10.1002/jbmr.2056

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Volume:
29
Issue:
3
Pages:
600-607
Publication date:
2014-03-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:9203f4e8-5098-4845-ac03-bc211c2e7cb1
Source identifiers:
135070
Local pid:
pubs:135070

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