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Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth.

Abstract:

Maternal vitamin D deficiency has been associated with reduced offspring bone mineral accrual. Retinoid-X receptor-alpha (RXRA) is an essential cofactor in the action of 1,25-dihydroxyvitamin D (1,25[OH]2 -vitamin D), and RXRA methylation in umbilical cord DNA has been associated with later offspring adiposity. We tested the hypothesis that RXRA methylation in umbilical cord DNA collected at birth is associated with offspring skeletal development, assessed by dual-energy X-ray absorptiometry,...

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Publication status:
Published

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Publisher copy:
10.1002/jbmr.2056

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Volume:
29
Issue:
3
Pages:
600-607
Host title:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Publication date:
2014-03-01
Event location:
United States
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
Source identifiers:
135070
Keywords:
Pubs id:
pubs:135070
UUID:
uuid:9203f4e8-5098-4845-ac03-bc211c2e7cb1
Local pid:
pubs:135070
Deposit date:
2013-11-17

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