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Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1.

Abstract:

The paraflagellar rod (PFR) of Trypanosoma brucei is a large, complex, intraflagellar structure that represents an excellent system in which to study flagellum assembly. Molecular ablation of one of its major constituents, the PFRA protein, in the snl-1 mutant causes considerable alteration of the PFR structure, leading to cell paralysis. Mutant trypanosomes sedimented to the bottom of the flask rather than staying in suspension but divided at a rate close to that of wild-type cells. This phe...

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Publication status:
Published

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Authors


Pullen, TJ More by this author
Sherwin, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Journal of cell science
Volume:
112 ( Pt 21)
Issue:
21
Pages:
3769-3777
Publication date:
1999-11-05
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:91ff22d5-abdb-405a-91e9-7357629cda24
Source identifiers:
30821
Local pid:
pubs:30821

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