Journal article
The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.
- Abstract:
-
Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of species. The similarities in anatomy and physiology to the human neuromuscular system, coupled with the ease of genetic manipulation, make the mouse the most suitable model for exploring the basic patho...
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- Publisher copy:
- 10.1242/dmm.007245
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Authors
Bibliographic Details
- Journal:
- Disease models and mechanisms
- Volume:
- 4
- Issue:
- 4
- Pages:
- 457-467
- Publication date:
- 2011-07-01
- DOI:
- EISSN:
-
1754-8411
- ISSN:
-
1754-8403
- Source identifiers:
-
245221
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:245221
- UUID:
-
uuid:91f86886-bf04-45c0-bec6-8c544d9e6cda
- Local pid:
- pubs:245221
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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