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Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay

Abstract:

Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulation studies have traditionally relied on radiolabelled chloroquine, which poses several challenges. There is a need for development of a safe and biologically relevant substitute. We report here a commercially-available green fluorescent ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
9
Issue:
10
Pages:
e110800
Publication date:
2014-10-24
Acceptance date:
2014-09-18
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:91f6ad53-3674-4eee-9778-a5fd1af27bb1
Local pid:
pubs:487450
Source identifiers:
487450
Deposit date:
2014-12-04

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