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Journal article

Sources of systematic bias in hypercapnia-calibrated functional MRI estimation of oxygen metabolism.

Abstract:

The change in cerebral rate of oxidative metabolism (CMR(O(2))) during neural activation may be estimated from blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) and arterial spin-labeling (ASL) fMRI measurements. The established method relies on an epoch of iso-metabolic blood flow increase, typically induced by CO2 breathing, to calibrate the BOLD-CBF relationship at resting-state CMR(O2). Here, we discuss the systematic bias in CMR(O2)-CBF data that can b...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
NeuroImage
Volume:
34
Issue:
1
Pages:
35-43
Publication date:
2007-01-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:91f688e1-895f-4f71-aa74-b4a31527a444
Source identifiers:
241936
Local pid:
pubs:241936

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