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Journal article

A small amount of fat does not affect piperaquine exposure in patients with malaria.

Abstract:

Dihydroartemisinin-piperaquine is a new, highly effective, and well-tolerated combination treatment for uncomplicated falciparum malaria. The lipophilic characteristic of piperaquine suggests that administration together with fat will increase the oral bioavailability of the drug, and this has been reported for healthy volunteers. This pharmacokinetic study monitored 30 adult patients with uncomplicated falciparum malaria for 4.5 months to evaluate the effects of the concomitant intake of fat...

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Publication status:
Published

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Publisher copy:
10.1128/aac.00279-11

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Journal:
Antimicrobial agents and chemotherapy More from this journal
Volume:
55
Issue:
9
Pages:
3971-3976
Publication date:
2011-09-01
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Language:
English
Keywords:
Pubs id:
pubs:179481
UUID:
uuid:91f65986-30d5-488f-a7d0-dba7ed2983c3
Local pid:
pubs:179481
Source identifiers:
179481
Deposit date:
2012-12-19

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