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Ultrasound-enhanced siRNA delivery using magnetic nanoparticle-loaded chitosan-deoxycholic acid nanodroplets

Abstract:

Small interfering RNA (siRNA) has significant therapeutic potential but its clinical translation has been severely inhibited by a lack of effective delivery strategies. Previous work has demonstrated that perfluorocarbon nanodroplets loaded with magnetic nanoparticles can facilitate the intracellular delivery of a conventional chemotherapeutic drug. The aim of this study was to determine whether a similar agent could provide a means of delivering siRNA, enabling efficient transfection without...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/adhm.201601246

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Department:
Oxford, MPLS, Engineering Science
de Saint Victor, M More by this author
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Publisher:
Wiley Publisher's website
Journal:
Advanced Healthcare Materials Journal website
Volume:
6
Issue:
8
Pages:
1601246
Publication date:
2017-02-13
Acceptance date:
2017-01-10
DOI:
ISSN:
2192-2659
Pubs id:
pubs:668980
URN:
uri:91f5fdf6-a544-46c9-acef-799be51f1024
UUID:
uuid:91f5fdf6-a544-46c9-acef-799be51f1024
Local pid:
pubs:668980

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