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Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly.

Abstract:

Mammalian pyruvate dehydrogenase complex (PDC) is a key multi-enzyme assembly that is responsible for glucose homeostasis maintenance and conversion of pyruvate into acetyl-CoA. It comprises a central pentagonal dodecahedral core consisting of two subunit types (E2 and E3BP) to which peripheral enzymes (E1 and E3) bind tightly but non-covalently. Currently, there are two conflicting models of PDC (E2+E3BP) core organisation: the 'addition' model (60+12) and the 'substitution' model (48+12). H...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2010.03.043

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Journal of molecular biology More from this journal
Volume:
399
Issue:
1
Pages:
71-93
Publication date:
2010-05-01
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Language:
English
Keywords:
Pubs id:
pubs:180381
UUID:
uuid:91e1c239-c204-4865-8034-7ca1118795ca
Local pid:
pubs:180381
Source identifiers:
180381
Deposit date:
2012-12-19

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