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Brain-expressed 3'UTR extensions strengthen miRNA cross-talk between ion channel/transporter encoding mRNAs.

Abstract:

Why protein-coding genes express transcripts with longer 3'untranslated regions (3'UTRs) in the brain rather than in other tissues remains poorly understood. Given the established role of 3'UTRs in post-transcriptional regulation of transcript abundance and their recently highlighted contributions to miRNA-mediated cross-talk between mRNAs, we hypothesized that 3'UTR lengthening enhances coordinated expression between functionally-related genes in the brain. To test this hypothesis, we annota...

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Publisher copy:
10.3389/fgene.2014.00041
Publisher:
Frontiers Research Foundation
Journal:
Frontiers in genetics More from this journal
Volume:
5
Issue:
FEB
Pages:
41
Publication date:
2014-01-01
DOI:
EISSN:
1664-8021
Language:
English
Keywords:
Pubs id:
pubs:456186
UUID:
uuid:91dd28f9-c6d4-4d07-b505-d530646db9f6
Local pid:
pubs:456186
Source identifiers:
456186
Deposit date:
2014-07-08

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