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Genetic variation at the ADAMTS7 locus is associated with reduced severity of coronary artery disease

Abstract:
Background– Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using histological, angiographic and clinical outcomes data. Methods and results– The lead CAD-associated single-nucleotide polymorphism rs3825807 at the AD... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/JAHA.117.006928

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Publisher:
American Heart Association
Journal:
Journal of the American Heart Association More from this journal
Volume:
6
Issue:
11
Article number:
e006928
Publication date:
2017-10-31
Acceptance date:
2017-10-03
DOI:
ISSN:
2047-9980
Keywords:
Pubs id:
pubs:734952
UUID:
uuid:91dcc8cc-7c92-4a8d-a914-6994de3d9e71
Local pid:
pubs:734952
Source identifiers:
734952
Deposit date:
2017-10-10

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