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Detection of activated lymphocytes in endocrine pancreas of BB/W rats by injection of 123I-interleukin-2: an early sign of type 1 diabetes.

Abstract:

Recombinant interleukin-2 (IL2) was labelled with iodine-123 by a modified chloramine T method. The labelled IL2, which had a high specific activity (100-150 microCi/microgram) and retained its capacity for binding to the IL2 receptor on activated lymphocytes in vitro, was injected intravenously into BB/W diabetes-prone and normal rats. Combined immunoperoxidase staining and autoradiography of organ sections revealed that labelled IL2 bound specifically in vivo to IL2-receptor-positive cells ...

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Authors


Signore, A More by this author
Pozzilli, P More by this author
Andreani, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
Lancet
Volume:
2
Issue:
8558
Pages:
537-540
Publication date:
1987-09-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:91d047ae-b180-4a55-9745-0fe61f72a37a
Source identifiers:
35256
Local pid:
pubs:35256

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