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NAADP-induced calcium release in sea urchin eggs.

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent activator of Ca2+ release from intracellular stores described. It acts on a mechanism distinct from inositol trisphosphate and ryanodine receptors, the two major Ca2+ release channels characterised. NAADP-gated Ca2+ release channels do not appear to be regulated by Ca2+ and may be better suited for triggering Ca2+ signals rather than propagating them. They exhibit a remarkable pharmacology for a putative intracellular Ca...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Biology of the cell / under the auspices of the European Cell Biology Organization
Volume:
92
Issue:
3-4
Pages:
197-204
Publication date:
2000-07-05
DOI:
EISSN:
1768-322X
ISSN:
0248-4900
URN:
uuid:91c616cf-883f-4137-8c8e-4194544c2baa
Source identifiers:
106455
Local pid:
pubs:106455

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