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Model validation and robust stability analysis of the bacterial heat shock response using SOSTOOLS

Abstract:

The complexity inherent in gene regulatory network models, as well as their nonlinear nature make them difficult to analyze or validate/invalidate using conventional tools. Combining ideas from robust control theory, real algebraic geometry, optimization and semidefinite programming, SOSTOOLS provides a promising framework to answer these robustness and model validation questions algorithmically. We adopt these tools in the study of the heat shock response in bacteria. For this purpose, we us...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Role:
Author
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Volume:
4
Pages:
3766-3771
Publication date:
2003-01-01
ISSN:
0191-2216
URN:
uuid:91c4fc00-c3ab-4990-ab60-5152cf5bf0b4
Source identifiers:
64472
Local pid:
pubs:64472
ISBN:
0-7803-7924-1

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