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Immunopolarization of CD4+ and CD8+ T cells to Type-1-like is associated with melanocyte loss in human vitiligo.

Abstract:

Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. High frequencies of melanocyte-reactive cytotoxic T cells in the peripheral blood of vitiligo patients and the observed correlation between perilesional T-cell infiltration and melanocyte loss in situ suggest the important role of cellular autoimmunity in the pathogenesis of this disease. We isolated T cells from both perilesional and nonlesional skin biopsies obtained from five vitiligo patients, then cloned ...

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Publication status:
Published

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Authors


Wańkowicz-Kalińska, A More by this author
van den Wijngaard, RM More by this author
Tigges, BJ More by this author
Westerhof, W More by this author
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Journal:
Laboratory investigation; a journal of technical methods and pathology
Volume:
83
Issue:
5
Pages:
683-695
Publication date:
2003-05-05
DOI:
EISSN:
1530-0307
ISSN:
0023-6837
URN:
uuid:91beb56a-7ee0-479c-b9df-4b24d01a729e
Source identifiers:
12422
Local pid:
pubs:12422

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