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PLCζ is the physiological trigger of the Ca(2+) oscillations that induce embryogenesis in mammals but offspring can be conceived in its absence

Abstract:

Activation of the egg by the sperm is the first, vital stage of embryogenesis. The sperm protein PLCζ has been proposed as the physiological agent that triggers the Ca(2+) oscillations that normally initiate embryogenesis. Consistent with this, recombinant PLCζ induces Ca(2+) oscillations in eggs and debilitating mutations in the PLCZ1 gene are associated with infertility in men. However, there has been no evidence that gene knockout of PLCζ abolishes the ability of sperm to induce Ca(2+) osc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.150227

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Funding agency for:
Hachem, A
Grant:
Academic Scholarship Award grant
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Funding agency for:
Hachem, A
Grant:
Academic Scholarship Award grant
Iraqi Higher Committee for Education Development More from this funder
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Publisher:
Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
144
Issue:
16
Pages:
2914-2924
Publication date:
2017-07-10
Acceptance date:
2017-07-01
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Source identifiers:
708135
Language:
English
Keywords:
Pubs id:
pubs:708135
UUID:
uuid:91bcf667-1c75-40b8-9ba0-830255b8072f
Local pid:
pubs:708135
Deposit date:
2017-08-07

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