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Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites.

Abstract:

The signature DNA lesion induced by ionizing radiation is clustered DNA damage. Gamma radiation-induced clustered DNA damage containing base lesions was investigated in plasmid DNA under cell mimetic conditions and in two cell lines, V79-4 (hamster) and HF19 (human), using bacterial endonucleases Nth (endonuclease III) and Fpg (formamidopyrimidine DNA glycosylase). Following irradiation with 60Co gamma-rays, induction of double-strand breaks (DSB) and clustered DNA damage, revealed as DSB by ...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkf467

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Nucleic acids research
Volume:
30
Issue:
15
Pages:
3464-3472
Publication date:
2002-08-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:91bc10b5-5339-4356-9c48-f608257efd95
Source identifiers:
131304
Local pid:
pubs:131304

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