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The pharmacological treatment of Alzheimer's disease with cholinesterase inhibitors and memantine

Abstract:

The treatment of Alzheimer's disease (AD) is now a fast evolving field of both basic scientific and clinical research. The use of the currently licensed cholinesterase inhibitor (ChEI) drugs is based on the findings in the midto- late 1970s, and early 1980s, of reduced levels of cholinergic markers in the brain of people who died with AD, mainly in the later stages of severe dementia. These changes were shown to correlate with the severity of pathological and clinical signs of the disease, an...

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Publisher copy:
10.1007/978-0-387-71522-3_3

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Publisher:
Springer New York
Pages:
36-49
Host title:
Pharmacological Mechanisms in Alzheimer's Therapeutics
Publication date:
2007
DOI:
URN:
uuid:91b74699-9da3-45c6-9a25-ff4dff208136
Source identifiers:
72455
Local pid:
pubs:72455
ISBN:
9780387715216

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