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Journal article

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.

Abstract:

Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here, we describe the finding of homozygous EZH2 mutations in 9 of 12 individuals with 7q acquired uniparental disomy. Screening of a total of 614 individuals with myeloid disorders revealed 49 monoallelic or biallelic EZH2 mutations in 42 individuals; the mutations were found most commonly in those with myelodysplastic/myeloproliferative neoplasms (27 out of 219 individua...

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Publication status:
Published

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Publisher copy:
10.1038/ng.621

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Journal:
Nature genetics
Volume:
42
Issue:
8
Pages:
722-726
Publication date:
2010-08-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:91b47f19-8079-40c5-b0d9-fd4685981f60
Source identifiers:
246251
Local pid:
pubs:246251

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