Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.

Ernst, T; Chase, AJ; Score, J; Hidalgo-Curtis, CE; Bryant, C; Jones, AV; Waghorn, K; Zoi, K; Ross, FM; Reiter, A; Hochhaus, A; Drexler, HG; Duncombe, A; Cervantes, F; Oscier, D; Boultwood, J; Grand, FH; Cross, NC

Abstract:

Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here, we describe the finding of homozygous EZH2 mutations in 9 of 12 individuals with 7q acquired uniparental disomy. Screening of a total of 614 individuals with myeloid disorders revealed 49 monoallelic or biallelic EZH2 mutations in 42 individuals; the mutations were found most commonly in those with myelodysplastic/myeloproliferative neoplasms (27 out of 219 individua...

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APA Style

Ernst, T., Chase, A. J., Score, J., Hidalgo-Curtis, C. E., Bryant, C., Jones, A. V., Waghorn, K., Zoi, K., Ross, F. M., Reiter, A., Hochhaus, A., Drexler, H. G., Duncombe, A., Cervantes, F., Oscier, D., Boultwood, J., Grand, F. H., & Cross, N. C. (2010). Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nature Genetics, 42(8), 722–726.

MLA Style

Ernst, T., et al. “Inactivating Mutations of the Histone Methyltransferase Gene EZH2 in Myeloid Disorders.” Nature Genetics, vol. 42, no. 8, 2010, pp. 722–26.

Chicago Style

Ernst, T, AJ Chase, J Score, CE Hidalgo-Curtis, C Bryant, AV Jones, K Waghorn, et al. 2010. “Inactivating Mutations of the Histone Methyltransferase Gene EZH2 in Myeloid Disorders.” Nature Genetics 42 (8): 722–26.
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