Journal article
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.
- Abstract:
-
Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here, we describe the finding of homozygous EZH2 mutations in 9 of 12 individuals with 7q acquired uniparental disomy. Screening of a total of 614 individuals with myeloid disorders revealed 49 monoallelic or biallelic EZH2 mutations in 42 individuals; the mutations were found most commonly in those with myelodysplastic/myeloproliferative neoplasms (27 out of 219 individua...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/ng.621
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Authors
Bibliographic Details
- Journal:
- Nature genetics
- Volume:
- 42
- Issue:
- 8
- Pages:
- 722-726
- Publication date:
- 2010-08-01
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Source identifiers:
-
246251
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:246251
- UUID:
-
uuid:91b47f19-8079-40c5-b0d9-fd4685981f60
- Local pid:
- pubs:246251
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2010
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