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Engineering synthetic signalling pathways with programmable dCas9-based chimeric receptors

Abstract:

Synthetic receptors provide a powerful experimental tool for generation of designer cells capable of monitoring the environment, sensing specific input signals, and executing diverse custom response programs. To advance the promise of cellular engineering, we have developed a class of chimeric receptors that integrate a highly programmable and portable nuclease-deficient CRISPR/Cas9 (dCas9) signal transduction module. We demonstrate that the core dCas9 synthetic receptor (dCas9-synR) architec...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.08.044

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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
More by this author
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
20
Issue:
11
Pages:
2639–2653
Publication date:
2017-09-12
Acceptance date:
2017-08-11
DOI:
ISSN:
2211-1247
Pubs id:
pubs:713682
URN:
uri:919daa0d-0993-4023-ae1a-5bc458058df4
UUID:
uuid:919daa0d-0993-4023-ae1a-5bc458058df4
Local pid:
pubs:713682

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