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Efficacy of a novel perfluorocarbon-based intrapulmonary drug delivery system

Abstract:

Introduction: We sought to determine the efficacy of a novel intrapulmonary perfluorocarbon (PFC) based antibiotic delivery system in a rat model of pneumococcal pneumonia. Methods: Wistar rats (400-500 g) were inoculated with 8x10' type 3 pneumococcus via direct intratracheal (IT) injection. Twenty-four h after inoculation, rats received no treatment (control, n=15), 10 mg IM ampicillin (AMP, n =10), 10 ml lavage with an AMP containing (1 mg/ml) microparticulate dispersion in PFC (AMPPFC; Al...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Critical Care Medicine More from this journal
Volume:
26
Issue:
1 SUPPL.
Publication date:
1998-01-01
ISSN:
0090-3493
Language:
English
Pubs id:
pubs:384066
UUID:
uuid:9199e62a-9268-475e-a87a-6002ea8df5ee
Local pid:
pubs:384066
Source identifiers:
384066
Deposit date:
2013-11-16

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