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The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.

Abstract:

The polarization of a neuron generally results in the formation of one axon and multiple dendrites, allowing for the establishment of neuronal circuitry. The molecular mechanisms involved in priming one neurite to become the axon, particularly those regulating the microtubule network, remain elusive. Here we report the identification of DOCK7, a member of the DOCK180-related protein superfamily, as a Rac GTPase activator that is asymmetrically distributed in unpolarized hippocampal neurons an...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neuron
Volume:
51
Issue:
6
Pages:
727-739
Publication date:
2006-09-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:9193d7a5-7ff5-4ba6-ac68-1b33eecb9036
Source identifiers:
185220
Local pid:
pubs:185220

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