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Myasthenia and related disorders of the neuromuscular junction

Abstract:

Our understanding of transmission at the neuromuscular junction has increased greatly in recent years. We now recognise a wide variety of autoimmune and genetic diseases that affect this specialised synapse, causing muscle weakness and fatigue. These disorders greatly affect quality of life and rarely can be fatal. Myasthenia gravis is the most common disorder and is most commonly caused by autoantibodies targeting postsynaptic acetylcholine receptors. Antibodies to muscle-specific kinase (Mu...

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Publisher copy:
10.1136/jnnp.2008.169367

Authors


Spillane, J More by this author
Beeson, DJ More by this author
Kullmann, DM More by this author
Journal:
Journal of Neurology, Neurosurgery and Psychiatry
Volume:
81
Issue:
8
Pages:
850-857
Publication date:
2010-08-05
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:91932d26-71d7-4e0d-81b5-19cfad1be748
Source identifiers:
243761
Local pid:
pubs:243761
Language:
English

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