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PET imaging of DNA damage using (89)Zr-labelled anti-γH2AX-TAT immunoconjugates.

Abstract:

PURPOSE: The efficacy of most anticancer treatments, including radiotherapy, depends on an ability to cause DNA double-strand breaks (DSBs). Very early during the DNA damage signalling process, the histone isoform H2AX is phosphorylated to form γH2AX. With the aim of positron emission tomography (PET) imaging of DSBs, we synthesized a (89)Zr-labelled anti-γH2AX antibody, modified with the cell-penetrating peptide, TAT, which includes a nuclear localization sequence. METHODS: (89)Zr-anti-γH2AX...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00259-015-3092-8

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Topping, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Cancer Research UK More from this funder
Medical Research Council More from this funder
Oxford Cancer Research Centre More from this funder
CRUK/EPRSC Cancer Imaging Centre More from this funder
Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
European journal of nuclear medicine and molecular imaging Journal website
Volume:
42
Issue:
11
Pages:
1707-1717
Publication date:
2015-10-05
DOI:
EISSN:
1619-7089
ISSN:
1619-7070
URN:
uuid:918c41ce-cafd-47ed-804d-b594abd3088a
Source identifiers:
526212
Local pid:
pubs:526212
Language:
English
Keywords:

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