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The radiosensitizing effects of Nelfinavir on pancreatic cancer with and without pancreatic stellate cells

Abstract:

Aims: We have previously shown in a phase I trial that nelfinavir (NFV) is safe with chemoradiation in PDAC with good signs for efficacy. Reverse translationally, we aimed to test the influence of PSCs on nelfinavir mediated radiosensitization to PDAC preclinically, because PDAC is very rich in desmoplasia and PSCs are known to mediate radioresistance.
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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
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Name:
Medical Research Council
Grant:
H3RMWX0
Publisher:
Elsevier
Journal:
Radiotherapy and Oncology More from this journal
Volume:
119
Issue:
2
Pages:
300-305
Publication date:
2016-05-28
Acceptance date:
2016-03-10
DOI:
EISSN:
1879-0887
ISSN:
0167-8140
Language:
English
Keywords:
Pubs id:
pubs:625291
UUID:
uuid:918c3240-8e55-436e-90a1-d3c5a7465328
Local pid:
pubs:625291
Source identifiers:
625291
Deposit date:
2016-06-07

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