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NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid

Abstract:

NI-0801 is a fully human monoclonal antibody against chemokine (C-X-C motif) ligand 10 (CXCL10), which is involved in the recruitment of inflammatory T cells into the liver. The safety and efficacy of NI-0801 was assessed in patients with primary biliary cholangitis. In this open-label phase 2a study, patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid received six consecutive intravenous administrations of NI-0801 (10 mg/kg) every 2 weeks. Patients w...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1002/hep4.1170

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ORCID:
0000-0003-0297-5189
Lapeyre, G More by this author
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ORCID:
0000-0001-7222-487X
Curbishley, SM More by this author
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Publisher:
Wiley Open Access Publisher's website
Journal:
Hepatology Communications Journal website
Volume:
2
Issue:
5
Pages:
492-503
Publication date:
2018-03-23
Acceptance date:
2018-02-22
DOI:
EISSN:
2471-254X
Pubs id:
pubs:853173
URN:
uri:91816844-45cf-4919-979e-1d955eba7e86
UUID:
uuid:91816844-45cf-4919-979e-1d955eba7e86
Local pid:
pubs:853173
Language:
English
Keywords:

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