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SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.

Abstract:

Inositol 1,4,5-trisphosphate (IP(3)) receptors are endoplasmic reticulum (ER) membrane calcium channels that, upon activation, become substrates for the ER-associated degradation (ERAD) pathway. While it is clear that IP(3) receptors are polyubiquitinated and are transferred to the proteasome by a p97-based complex, currently very little is known about the proteins that initially select activated IP(3) receptors for ERAD. Here, we have transfected HeLa cells to stably express m3 muscarinic re...

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Publication status:
Published

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Authors


Pearce, MM More by this author
Sliter, DA More by this author
Olzmann, JA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
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Journal:
Biochimica et biophysica acta
Volume:
1793
Issue:
11
Pages:
1710-1718
Publication date:
2009-11-05
DOI:
ISSN:
0006-3002
URN:
uuid:917bd38c-5806-4e18-b860-4381f46ea0f8
Source identifiers:
53529
Local pid:
pubs:53529

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