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Journal article

SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.

Abstract:

Inositol 1,4,5-trisphosphate (IP(3)) receptors are endoplasmic reticulum (ER) membrane calcium channels that, upon activation, become substrates for the ER-associated degradation (ERAD) pathway. While it is clear that IP(3) receptors are polyubiquitinated and are transferred to the proteasome by a p97-based complex, currently very little is known about the proteins that initially select activated IP(3) receptors for ERAD. Here, we have transfected HeLa cells to stably express m3 muscarinic re...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Journal:
Biochimica et biophysica acta More from this journal
Volume:
1793
Issue:
11
Pages:
1710-1718
Publication date:
2009-11-01
DOI:
ISSN:
0006-3002
Language:
English
Keywords:
Pubs id:
pubs:53529
UUID:
uuid:917bd38c-5806-4e18-b860-4381f46ea0f8
Local pid:
pubs:53529
Source identifiers:
53529
Deposit date:
2012-12-19

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