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The role of hypoxia in urological malignancies

Abstract:

Hypoxia, a state of low oxygen, is a feature of most solid tumours as a consequence of poor tumour vascularisation. The mechanisms, which allow cancer cells to survive and continue to grow in hypoxia, are coordinated by the transcription factor HIF. The tumour suppressor gene von Hippel-Lindau (vHL) that targets HIF for degradation is mutated in the vast majority of renal cell carcinomas (RCCs), highlighting the importance of hypoxia to tumour biology. There is, therefore, an important nee...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Christ Church
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Language:
English
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