GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

Journal article

Glucagon secretion is inhibited by glucagon-like peptide-1 (GLP-1) and stimulated by adrenaline. These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. The expression of GLP-1 receptors in alpha cells is <0.2% of that in beta cells. The GLP-1-induced suppression of glucagon secretion is PKA dependent, is glucose independent, and does not involve paracrine effects mediated by insulin or somatostatin. GLP-1 is w...

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Authors: De Marinis, Y; Salehi, A; Ward, C; Zhang, Q; Abdulkader, F

• Publication status: Published
• Journal: Cell metabolism
• Volume: 11
• Issue: 6
• Pages: 543-553
• Publication date: 2010-06-01
• DOI: 10.1016/j.cmet.2010.04.007
• EISSN: 1932-7420
• ISSN: 1550-4131
• Language: English
• Keywords: Animals; Glucagon-Like Peptide 1; Cells, Cultured; Guanine Nucleotide Exchange Factors; Cyclic AMP; Glucagon; Mice, Inbred C57BL; Calcium Channels, N-Type; Exocytosis; Epinephrine; Membrane Potentials; Carrier Proteins; Islets of Langerhans; Calcium Channels, L-Type; Colforsin; Cyclic AMP-Dependent Protein Kinases; Mice