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GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

Abstract:

Glucagon secretion is inhibited by glucagon-like peptide-1 (GLP-1) and stimulated by adrenaline. These opposing effects on glucagon secretion are mimicked by low (1-10 nM) and high (10 muM) concentrations of forskolin, respectively. The expression of GLP-1 receptors in alpha cells is <0.2% of that in beta cells. The GLP-1-induced suppression of glucagon secretion is PKA dependent, is glucose independent, and does not involve paracrine effects mediated by insulin or somatostatin. GLP-1 is w...

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Publication status:
Published

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Publisher copy:
10.1016/j.cmet.2010.04.007

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Journal:
Cell metabolism
Volume:
11
Issue:
6
Pages:
543-553
Publication date:
2010-06-01
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
Source identifiers:
58629

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