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The human and mouse GATA-6 genes utilize two promoters and two initiation codons.

Abstract:

GATA-6 has been implicated in the regulation of myocardial differentiation during cardiogenesis. To determine how its expression is controlled, we have characterized the human and mouse genes. We have mapped their transcriptional start sites and demonstrate that two alternative promoters and 5' noncoding exons are utilized. Both transcript isoforms are expressed in the same tissue-specific and developmental stage-specific pattern, and their ratio appears similar wherever examined. The more up...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.274.53.38004

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Journal:
Journal of biological chemistry More from this journal
Volume:
274
Issue:
53
Pages:
38004-38016
Publication date:
1999-12-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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