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MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

Abstract:

MDMX is overexpressed in the vast majority of patients with acute myeloid leukemia (AML). We report that MDMX overexpression increases preleukemic stem cell (pre-LSC) number and competitive advantage. Utilizing five newly generated murine models, we found that MDMX overexpression triggers progression of multiple chronic/asymptomatic preleukemic conditions to overt AML. Transcriptomic and proteomic studies revealed that MDMX overexpression exerts this function, unexpectedly, through activation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ccell.2021.02.006

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Publisher:
Cell Press
Journal:
Cancer Cell More from this journal
Volume:
39
Issue:
4
Pages:
529-547
Publication date:
2021-03-04
Acceptance date:
2021-02-08
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
Language:
English
Keywords:
Pubs id:
1166178
Local pid:
pubs:1166178
Deposit date:
2021-04-01

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